Niacinamide

Niacinamide is available in several forms of release depending on the use, including:

• Dietary supplements - These are generally available in 500 mg capsules for oral administration.
• Dermocosmetic products - Niacinamide is commonly used in serums, moisturisers and lotions for skin care, as an active ingredient in formulations aimed at improving acne and reducing the signs of ageing.

Niacinamide is mainly used for the following purposes:

• Treatment of skin conditions - Due to its anti-inflammatory properties, niacinamide is effective in reducing the symptoms associated with acne and rosacea, helping to even out skin tone

• Prevention of hyperpigmentation - It helps fade pigmentation spots and brighten the complexion, making it useful in reducing the signs of ageing

• Reduction of inflammation - It helps reduce redness and irritation caused by inflammatory skin conditions.

The dosage of niacinamide varies depending on the form of administration:

• Oral supplements - a daily intake of 500 mg is generally recommended, but it is essential to consult a doctor to determine the correct dose for your individual needs

• Topical use - cosmetic products usually contain concentrations of 2-10% niacinamide, and applications can be made 1-2 times a day, depending on skin sensitivity.

People with known hypersensitivity to vitamin B3 should avoid using it.

Also, people with liver disease, stomach ulcers or bleeding disorders should avoid oral supplements with niacinamide unless advised by a doctor.

People with certain pre-existing skin conditions should consult a dermatologist before using topical products containing niacinamide.

To maximise the benefits of niacinamide, it is recommended to use this ingredient in combination with other active substances.

• Niacinamide can be used together with vitamin C to enhance anti-ageing and skin brightening effects.
• Combining a serum containing niacinamide with retinol can increase the latter's effectiveness in reducing fine lines, while minimising the irritation that can often occur with retinol use.

Although niacinamide is generally well tolerated, some people may experience side effects such as allergic reactions, skin irritation, redness, itching or a burning sensation, especially with excessive use or on sensitive skin.

When taken orally, high doses of niacinamide can sometimes cause gastrointestinal discomfort, dizziness or headaches.

There are possible interactions between niacinamide and medicines that affect blood clotting, which may require careful monitoring of patients taking these medicines.

It is recommended that people taking medications, especially for chronic conditions, consult with a doctor or pharmacist before starting to use niacinamide.

Overdose of niacinamide is rare but can lead to significant adverse effects, including liver or gastrointestinal disorders.

If an overdose is suspected, it is important to contact a medical professional immediately.

Niacinamide should be stored in optimal conditions to maintain its effectiveness, in a cool, dry place, out of the reach of children.

Products containing niacinamide should be stored in tightly closed containers to prevent contamination and exposure to UV light, which can affect the integrity of the ingredient.

• PubMed, Mechanical basis and clinical evidence for the applications of Nicotinamide (Niacinamide) for the control of skin ageing and pigmentation
• WebMD, Niacinamide
• Healthline, Niacinamide
• Cleveland Clinic, Top 6 benefits of niacinamide