Antiparasitic pipettes for very large dogs 40-60 kg Fypryst Combo Dog XL 402 mg, 3 pipettes, Krka

Indications:
- treatment of flea infestation or mixed infestations with ticks and/or hematophagous lice in dogs;
- treatment of flea infestations (Ctenocephalides spp.);
- the insecticidal efficacy against reinfestations with adult fleas persists for 8 weeks;
- preventing the multiplication of fleas by inhibiting the development of eggs (ovicidal action) and larvae and pupae (larvicidal action) that come from the eggs laid by adult fleas persist 8 weeks after applying the product;
- treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus);
- the product has acaricidal efficacy of up to 4 weeks against ticks;
- treatment of infestations with hematophagous lice (Trichodectes canis);
- the product can be used as part of the treatment strategy for the control of allergic dermatitis caused by fleas (DAP), previously diagnosed by the veterinarian.

Mode of administration:
Route of administration and quantities to be administered: Only for external use.
Administer by topical application to the skin, according to body weight, as follows:
Dogs over 40 kg
Number of pipettes: 1 pipette
Volume of pipettes: 4.02 ml
Concentration (Fipronil + S-methoprene: 402 mg + 361.8 mg
In this way, a minimum recommended dose of fipronil of 6.7 mg/kg and a dose of S-methoprene of 6 mg/kg is provided after topical application to the skin.
1. Remove a pipette from the package. Hold the pipette in a vertical position with the tip up and unscrew the pipette cap.
2. With the other end of the stopper thus removed, pierce the pipette seal, then remove the cap.
3. Remove the animal's hair from the midline between the shoulder blades to expose the skin. Place the tip of the pipette on the skin and squeeze the tube several times to empty directly onto the skin in one place.

Active substance per pipette 4.02 ml:
Fipronil 402 mg
S-methoprene 361.80 mg
Excipients:
Butylhydroxyanisole (E320) 0.80 mg
Butylhydroxytoluene (E321) 0.40 mg

Contraindications:
In the absence of available data, the product is not administered to puppies less than 8 weeks old and/or weighing less than 2 kg.
Do not administer the product to sick animals (systemic diseases, fever) or to those in convalescence.
The product should not be administered to rabbits, due to the risk of serious adverse reactions or even death.
Since no clinical studies have been performed, the use of the product in other animal species outside the target species is not recommended.
The product is indicated especially for dogs.
Do not administer to domestic cats and ferrets, as overdose may occur.

Adverse reactions:
Among the very rare suspected adverse reactions, transient skin reactions at the site of drug application (discoloration and hair loss, itching and erythema) and general itching or alopecia can be observed.
Exceptionally, reversible neurological symptoms (hyperesthesia, depression, other neurological signs), hypersalivation, vomiting or respiratory symptoms have been observed after use.
If animals lick, short-term hypersalivation may occur, mainly due to the excipients.
Avoid overdose.
If you notice serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Precautions:
Keep out of sight and reach of children.
Store at temperatures below 30 C.
Store in the original packaging, to protect from light and moisture.
Do not use this veterinary product after the expiry date marked on the label.
Data on the effectiveness of the product after bathing/shampooing the animals are insufficient, therefore this practice is not recommended for 2 days after the application of the medicine.
Emollient shampoos can be used before treatment, but if used weekly, they reduce the duration of protection against fleas to about 5 weeks.
Weekly bathing with 2% chlorhexidine medicated shampoo does not affect the effectiveness of the product against fleas, as shown in studies conducted over a period of 6 weeks.
Dogs should not be allowed to swim in watercourses for 2 days after applying the product.
Ticks may appear sporadically. Thus, it is impossible to completely exclude infection with diseases in unfavorable conditions.
Pet fleas often infest the pet's litter box, bedding and common resting areas such as carpets and other soft materials, which should be treated with a suitable insecticide and vacuumed regularly in case of heavy infestation and when control measures are initiated.
Avoid contact of the product with the eyes of animals.
It is important to make sure that the application of the product is done in a safe place where the animal cannot lick and it must be avoided that the animals lick each other after applying the treatment.
The product can be applied to pregnant females, as well as lactating females.
Studies on the safety of the product in puppies aged up to 8 weeks and with a body weight of around 2 kg, treated monthly with doses 5 times higher than the recommended dose, have shown that there are no unwanted effects.
The risk of unwanted reactions increases with overdose (see point 6), therefore always use the pipette with the dose corresponding to the weight of the animal.
The product can cause irritation of mucous membranes, skin and eyes. Therefore, avoid contact of the product with the mouth, skin and eyes.
People with known hypersensitivity to insecticides or alcohol should avoid contact with the product.
Avoid direct hand contact with the product.
In case of accidental contact, wash hands with soap and water.
In case of contact with eyes, wash abundantly with clean water.
Wash hands after use.
Do not smoke, drink or eat while applying the product.
Do not touch the treated animals and do not let children play with them until the place of application of the product has dried. That is why it is not recommended to apply the treatment during the day but in the evening before going to bed, and the animals will not be allowed to sleep with the owners and especially with the children.

Presentation:
3 pipettes